The 58th number: 64,320,987,654,320,987,654,320,987,654,320,987,654,320,987,654,320,987,654,321
is the first in the sequence to be prime.
The 40th number: 44,320,987,654,320,987,654,320,987,654,320,987,654,321
is tempting as it doesn’t have any prime factors smaller than 78 million, but it is in fact composite.
Several others only have two prime factors.